PCA-Rx is Awaken's living breakthrough solution to toxicity in the body. Without knowing it, people go through life involuntarily collecting a variety of toxins, metals, and other contaminants in their bodies. Everyday circumstances like the air we breathe, the food we eat, disease vaccinations, prescription drugs, and even the place each of us calls home all contribute to the degree of toxic exposure we can experience and eventually suffer from. PCA-Rx / Oral Chelation Resources |
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Monday, 25 February, 2002
Heavy Metal Toxicity, Children’s Behavioral Disorders, and Oral Clathration Therapy
The Most Profound Science of Our Time
| Editor’s Note: A chelate is a chemical that will perform chelation, defined as the reaction between a metal ion and the complexing agent, resulting in formation of ring structures incorporating the ion. A clathrate is a cage structure capable of including another compound within its own structure. |
Chelation therapy may be described as a one-dimensional process. In contrast, oral clathration is a three-dimensional process. Specifically-sequenced glycoproteins and peptides form a lattice or inclusion complex and multiple receptor sites attach to a toxic molecule with irreversible bonds, literally wrapping around the toxic substance to prevent additional reactions with tissues or organs as it is eliminated from the body. Unlike the ionic bond utilized to transport metals from the body with chelation therapy, oral clathration therapy utilizes ionic, covalent and hydrogen bonds. Not one but three major types of bonds at multiple points are created.
Clinical reports indicate clathration therapy might be a more effective heavy metal detoxification therapy than conventional methods of chelation therapy. Thus, clathration therapy holds significant benefits when used as part of a comprehensive complementary medicine program, as noted in the case of children experiencing certain behavioral disorders.
David Steinman’s use of PCA-Rx from ASN™/Maxam™ Nutraceutics™ produced better detoxification results than dimercaptosuccinic acid (DMSA) or dimercaptopropane sulfonate (DMPS) for Aaron Corbett. Diagnosed with heavy metal poisoning by his physician, Aaron's parents Brian and Joan suspect their son developed autism as a result of vaccination-related heavy metal contamination. In a recent report published in The Doctors' Prescription for Healthy Living, it was noted that many children experiencing behavioral problems (including attention deficit/hyperactivity disorder, violent and antisocial behavior, and decreased IQ) have received benefits from PCA-Rx when used as part of a comprehensive complementary medicine program.
What is the role of heavy metal toxicity in children with developmental delays and other neurological and metabolic disorders? The answer may be surprising to many parents. In fact, the extent of impact on children with some of our commonest neurological disorders – including autism, attention deficit/hyperactivity disorder, and aggressive and violent behavior – may be far greater than parents and doctors have hitherto suspected. Let’s look at some of the evidence:
In 1983, a study published in Medical Hypotheses noted that the concentration of a number of metals determined in the hair of 68 hyperactive children, when compared with a control group, indicated excessive levels of manganese and reduced levels of zinc.
In 1989, researchers involved with the Edinburgh Lead Study studied the effect of blood lead on children’s behavior in a sample of 501 boys and girls aged six to nine years from 18 primary schools. Teachers and parents using behavior scales made behavior ratings of the children. Analyses showed a significant relationship between blood lead levels and teachers’ ratings on the total behavioral scores, as well as aggressive/antisocial and hyperactive scores. A dose-response relationship between blood lead levels and behavior ratings was evident. No evidence of a threshold effect could be found. In other words, even low levels adversely influenced behavior.
In a 1996 study from the Archives of Environmental Health, the relationship between hair lead levels of children and their attention-deficit behaviors in the classroom was investigated. Scalp hair specimens were obtained from 277 first-grade pupils, while teachers completed the abbreviated Boston Teacher’s Rating Scale for rating classroom attention-deficit behavior and parents completed a short questionnaire. “The striking dose response relationship between levels of lead and negative teacher ratings remained significant after controlling for age, ethnicity, gender, and socioeconomic status,” the report noted. “An even stronger relationship existed between physician-diagnosed attention-deficit hyperactivity disorder and hair lead in the same children.” Once again, “no apparent ‘safe’ threshold for lead” could be found with even the lowest exposures.
Chelation/Clathration Aid Children with Behavioral Disorders
In another study, children with clear-cut hyperactivity disorder and moderately-elevated lead levels were treated with a lead-chelating agent in a random allocation double-blind treatment regimen. “Statistically significant and obvious behavioral improvement was reported by three separate evaluators (i.e., parent, teacher, and treating physician) of the child, suggesting a toxic relationship between moderately-elevated lead levels and hyperactivity,” note the researchers.
Agents frequently used for heavy metal chelation include ethylene diaminetetraacetic acid (EDTA), DMSA, d-penicillamine, and dimercaptoproponol. These are often given in oral doses, alone or in combination. But a superior long-term strategy may be to combine chelation with oral clathration therapy. The best such examples of oral clathration agents are PCA and PCA-Rx from ASN™/Maxam™ Nutraceutics™. PCA-Rx is said to have a high bonding affinity for heavy metals. (See clinical case reports.) Most toxins or heavy metals that attach to cell receptors do so in a manner that is competitively reversible, so if molecules like those in PCA-Rx come along with greater affinity, the toxins can be dislodged from the receptors, which then once again can be receptive to neurotransmitters.
| FYI: How Metals Are Clathrated Metals are clathrated by PCA-Rx in the following order due to their descending valences: lead, thallium, cadmium, arsenic, aluminum, and mercury. This is important to note because if patients’ systems are saturated with lead or another heavy metal, their urine mercury readings will not drop until they have clathrated the metals with higher valences. |
Because of the formula’s tremendous affinity for heavy metals, this is an improvement over chelation therapy, which has a much more difficult time removing heavy metals from cell receptors. In February, we detailed the experience of a Troy, Michigan, couple whose child was diagnosed with autism that may have resulted from or been exacerbated by such toxicity. The couple notes that the oral clathration agent, combined with ionic minerals, proved to be equally or more effective as their son’s DMSA/DMPS treatments yet without side effects. A combination of the oral clathration agent and ionic mineral supplements increased their child’s heavy metal output by two to three times (as measured by urinalysis) over chelation therapy. The couple is quoted as telling the publication, “In two months, we had the same benefits with PCA-Rx and ionic minerals as using DMSA for an entire year. Also, unlike DMSA, PCA-Rx will not chelate beneficial minerals, one reason it is less stressful to the child’s body.”
| QUICK DEFINITION Clathrate: Relating to or being a compound formed by the inclusion of molecules of one kind in cavities of the crystal lattice of another. |
How PCA-Rx Works: PCA-Rx is different from other chelating agents, and we believe it represents a major breakthrough in personal detoxification.
Utilizes Clathration.
PCA-Rx works on the principle of clathration. Its contingent of specifically sequenced peptides form a lattice or inclusion complex. This represents a true breakthrough in the field of oral chelating agents.
Detoxification with a Peptide Clathrating Agent.
Most of us have heard of chelation therapy. Physicians and doctors have utilized chelation therapy for years to cleanse their patients’ bodies of lead and other heavy metal contaminants. PCA-Rx from ASN™/Maxam™ Nutraceutics™ is the first peptide clathration formula ever created for natural detoxification. Not only is it among the most effective chelating agents now in practice; it is available to consumers over-the-counter at natural health centers and from health professionals.
Nutrient Particles Measured in Nanometers. We usually think of the amounts included of particular nutritional supplements in terms of milligrams and micrograms. But PCA-Rx nutrient particles are formulated in the range of nanometers – reduced to their bare peptide essential configuration – and placed in a natural colloid. The body recognizes these peptides as nutrients.
Affinity for Cell Membranes. Each nutrient particle carries a negative surface charge and cells contain a positive surface charge, so absorption occurs electrokinetically, which is a much more efficient method of absorption than osmosis where 50 percent maximum levels may be achieved at best. Because of the particle size and bare, stripped-down nature of the peptides, the PCA-Rx nutrients gain access into the mitochondria of the cell. There, a peptide ligand complex binds with greater affinity to cell receptor sizes than heavy metals, releasing the heavy metals. The companion molecules then clathrate (wrap around and enclose) the toxic substance, keeping it enclosed as it enters the body’s elimination pathways. The bond is a strong one, too. PCA-Rx’s nutrients bond to toxic chemicals with ionic, covalent and hydrogen bonds as compared to DMPS (the most commonly-used chelation agent), which utilizes only an ionic bond.
Does Not Remove Beneficial Minerals. PCA-Rx will not bind to beneficial minerals because those that belong in the body are tightly bound and protected by their natural enzymes. Heavy metals and toxins do not have enzyme systems to protect them. PCA-Rx targets noncomplexed, loosely-bound metals. If there is an excess of natural mineral in the body (as with calcium-based plaques), PCA-Rx will also bind to these and remove them. Metals are clathrated in the following prioritized order due to their descending valences: lead, thallium, cadmium, arsenic, aluminum, and mercury. This is important to note because if your system is saturated with lead or another heavy metal, your urine mercury readings will not drop until you have clathrated the metals with higher valences.
FYI: Monitoring Detoxification |
