ARI Publication 40 – 2013 Version

Ito H etal, Rndingsofbrain 99mTc-EGJSPECTin high-li.Jnctioningautism-3-dimensionalstereotadicROItemplate
analysisofbrain SPECT. J MedInvest. 2005Feb;52(1-2):49-56. (15d7i/clren with autism, 5 d7ilclren with
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a segmental quantitative SPECTstudy. Indian Pediatr. 2009 Feb;46(2):161-4. (10 children with
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Research on effect of HBOT on brain hypoperfusion
HBOT has been reported to at least temporarily improve brain hypoperfusion in two open-label
studies of other conditions (veterans with post-concussion syndrome and patients with various
chronic brain injuries).

Harch P, et al A Phase I Study ofLow Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post
Concussion Syndrome and Post Traumatic Stress Disorder.
J Neurotrauma 2012, 29(1):168-185.
Golden ZL et al, A: Improvement in cerebral metabolism in chronic brain injury after hyperbaric oxygen
therapy. Int
J Neurosci 2002, 112(2):11~131.

Formal research studies of the possible effect of HBOT on brain hypoperfusion in individuals with
autism are needed to determine if it is helpful. Investigation of the effect on inflammation, such as
elevations of CRP, would also be very useful.